MolNFT v1 · #57592 · protein

Crystal structure of hypoxanthine-guanine phosphoribosyltransferase with imp from thermus thermophilus HB8

3ACD: “Crystal structure of hypoxanthine-guanine phosphoribosyltransferase with imp from thermus thermophilus HB8”. X-ray diffraction, 1 ligand (IMP), 1 pocket (best druggability 0.49). MolNFT v1 #57592 on GenesisL1: 3D structure, binding…

PDB: 3ACD
Type: protein
Length: 164 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hypoxanthine-guanine phosphoribosyltransferase
EC: 2.4.2.8
UniProt: Q5SLS3
Ligands: IMP
Pockets: 1 · best druggability 0.49

Structure

x-ray diffraction · 1 distinct chain · 24% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)	protein	164	24% helix, 30% strand	Q5SLS3

Ligands and binding sites

IMP · Inosinic acid · ligand · chains A
DIO · 1,4-diethylene dioxide · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	196	0.49	0.76	23	IMP

Compared structures

3ACD · Crystal structure of hypoxanthine-guanine phosphoribosyltransferase with IMP from Thermus… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5SLS3
Elsewhere: RCSB PDB 3ACD · PDBe 3ACD · UniProt Q5SLS3

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