MolNFT v1 · #57432 · protein
Human MST3 kinase
3A7G · SERINE/THREONINE kinase 24 (STE20 homolog, yeast): “Human MST3 kinase”. X-ray diffraction, 3 pockets (best druggability 0.76). MolNFT v1 #57432 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3A7G
- Type
- protein
- Length
- 581 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE kinase 24 (STE20 homolog, yeast)
- UniProt
- Q6P0Y1
- Pockets
- 3 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE kinase 24 (STE20 homolog, yeast) | protein | 290 | 42% helix, 19% strand | Q6P0Y1 |
| B | SERINE/THREONINE kinase 24 (STE20 homolog, yeast) | protein | 291 | 40% helix, 19% strand | Q6P0Y1 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1127 | 0.76 | 0.78 | 82 | empty |
| 2 | 409 | 0.67 | 0.80 | 38 | empty |
| 3 | 405 | 0.67 | 0.80 | 39 | empty |
Interfaces
1 interface between chains.
- A–B · 493 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 3A7G · Human MST3 kinase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P0Y1
- Elsewhere: RCSB PDB 3A7G · PDBe 3A7G · UniProt Q6P0Y1
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