MolNFT v1 · #57089 · protein
Crystal structure of a periplasmic substrate binding protein in complex with zinc and lactate
2ZZW · ABC transporter, solute-binding protein: “Crystal structure of a periplasmic substrate binding protein in complex with zinc and lactate”. X-ray diffraction, 2 ligands (LAC, ZN), 4 pockets (best druggability 0.70). MolNFT v1 #57089…
- PDB
- 2ZZW
- Type
- protein
- Length
- 660 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ABC transporter, solute-binding protein
- UniProt
- Q5SK82
- Ligands
- LAC, ZN
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | ABC transporter, solute-binding protein | protein | 330 | 50% helix, 15% strand | Q5SK82 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 455 | 0.70 | 0.80 | 45 | empty |
| 2 | 478 | 0.69 | 0.80 | 38 | empty |
| 3 | 163 | 0.45 | 0.75 | 25 | empty |
| 4 | 166 | 0.44 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1378 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 2ZZW · Crystal Structure of a Periplasmic Substrate Binding Protein in Complex with Zinc and… · the same entry in another collection · chain A against A, TM-score 1.00
- Q5SK82 · AlphaFold monomer V2.0 prediction for lactate-binding periplasmic protein TTHA0766… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SK82
- Elsewhere: RCSB PDB 2ZZW · PDBe 2ZZW · UniProt Q5SK82
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