MolNFT v1 · #56999 · protein
Alpha-L-fucosidase complexed with inhibitor, F10-2C-O
2ZX8 · Alpha-L-fucosidase, putative: “Alpha-L-fucosidase complexed with inhibitor, F10-2C-O”. X-ray diffraction, 1 ligand (ZX8), 9 pockets (best druggability 0.71). MolNFT v1 #56999 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2ZX8
- Type
- protein
- Length
- 882 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-L-fucosidase, putative
- EC
- 3.2.1.51
- UniProt
- Q9WYE2
- Ligands
- ZX8
- Pockets
- 9 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Alpha-L-fucosidase, putative (EC 3.2.1.51) | protein | 441 | 33% helix, 19% strand | Q9WYE2 |
Ligands and binding sites
- ZX8 · N-{[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl}-1-benzofuran-2-carboxamide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 911 | 0.71 | 0.76 | 61 | empty |
| 2 | 262 | 0.59 | 0.79 | 32 | ZX8 |
| 3 | 286 | 0.59 | 0.78 | 42 | ZX8 |
| 4 | 92 | 0.35 | 0.74 | 15 | empty |
| 5 | 50 | 0.33 | 0.78 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 839 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 2ZX8 · alpha-L-fucosidase complexed with inhibitor, F10-2C-O · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WYE2
- Elsewhere: RCSB PDB 2ZX8 · PDBe 2ZX8 · UniProt Q9WYE2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.