MolNFT v1 · #56976 · protein
Crystal structure of ALPHA/BETA-galactoside alpha-2,3- sialyltransferase from a luminous marine bacterium, <I>PHOTOBACTERIUM PHOSPHOREUM</I>
2ZWI · Alpha-/beta-galactoside alpha-2,3-sialyltransferase: “Crystal structure of ALPHA/BETA-galactoside alpha-2,3- sialyltransferase from a luminous marine bacterium…”. X-ray diffraction, 3 ligands (C5P, ZN, CL), 5 pockets (best…
- PDB
- 2ZWI
- Type
- protein
- Length
- 743 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-/beta-galactoside alpha-2,3-sialyltransferase
- EC
- 2.4.99.4
- UniProt
- A5LHX0
- Ligands
- C5P, ZN, CL
- Pockets
- 5 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-/beta-galactoside alpha-2,3-sialyltransferase (EC 2.4.99.4) | protein | 370 | 44% helix, 19% strand | A5LHX0 |
| B | Alpha-/beta-galactoside alpha-2,3-sialyltransferase (EC 2.4.99.4) | protein | 373 | 43% helix, 18% strand | A5LHX0 |
Ligands and binding sites
- C5P · Cytidine-5'-monophosphate · ligand · 2 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
- CL · Chloride ion · ion · 4 copies · chains A, B
- GOL · Glycerol · additive · 9 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 511 | 0.84 | 0.90 | 71 | GOL |
| 2 | 229 | 0.73 | 0.88 | 37 | C5P, GOL |
| 3 | 442 | 0.71 | 0.82 | 60 | GOL |
| 4 | 234 | 0.56 | 0.78 | 34 | C5P, GOL |
| 5 | 96 | 0.40 | 0.77 | 20 | GOL |
Interfaces
1 interface between chains.
- A–B · 1075 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2ZWI · Crystal structure of alpha/beta-Galactoside alpha-2,3-Sialyltransferase from a Luminous… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A5LHX0
- Elsewhere: RCSB PDB 2ZWI · PDBe 2ZWI · UniProt A5LHX0
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