MolNFT v1 · #56879 · protein

Mtruva form III

2ZTD · Holliday junction ATP-dependent DNA helicase ruva: “Mtruva form III”. X-ray diffraction, 1 pocket (best druggability 0.55). MolNFT v1 #56879 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2ZTD
Type: protein
Length: 371 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Holliday junction ATP-dependent DNA helicase ruva
EC: 3.6.1.-
UniProt: P66744
Pockets: 1 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Holliday junction ATP-dependent DNA helicase ruva (EC 3.6.1.-)	protein	189	46% helix, 21% strand	P66744
B	Holliday junction ATP-dependent DNA helicase ruva (EC 3.6.1.-)	protein	182	47% helix, 23% strand	P66744

Ligands and binding sites

GOL · Glycerol · additive · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	243	0.55	0.77	35	empty

Interfaces

1 interface between chains.

A–B · 1300 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

2ZTD · MtRuvA Form III · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P66744
Elsewhere: RCSB PDB 2ZTD · PDBe 2ZTD · UniProt P66744

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