MolNFT v1 · #56847 · protein
Structural basis of GIBBERELLIN(GA3)-induced della recognition by the gibberellin receptor
2ZSH · Probable gibberellin receptor GID1L1: “Structural basis of GIBBERELLIN(GA3)-induced della recognition by the gibberellin receptor”. X-ray diffraction, 1 ligand (GA3), 5 pockets (best druggability 0.79). MolNFT v1 #56847 on…
- PDB
- 2ZSH
- Type
- protein
- Length
- 397 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable gibberellin receptor GID1L1; Della protein gai
- UniProt
- Q9MAA7, Q9LQT8
- Ligands
- GA3
- Pockets
- 5 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable gibberellin receptor GID1L1 | protein | 338 | 35% helix, 17% strand | Q9MAA7 |
| B | Della protein gai | protein | 59 | 61% helix, 7% strand | Q9LQT8 |
Ligands and binding sites
- GA3 · Gibberellin A3 · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 425 | 0.79 | 0.87 | 54 | GA3 |
| 2 | 52 | 0.69 | 0.97 | 17 | empty |
| 3 | 121 | 0.42 | 0.76 | 27 | empty |
| 4 | 61 | 0.36 | 0.78 | 16 | empty |
| 5 | 58 | 0.27 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1334 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 2ZSH · Structural basis of gibberellin(GA3)-induced DELLA recognition by the gibberellin receptor · the same entry in another collection · chain A against A, TM-score 1.00
- Q9MAA7 · AlphaFold monomer V2.0 prediction for gibberellin receptor GID1A (Q9MAA7) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9LQT8 · AlphaFold monomer V2.0 prediction for della protein gai (Q9LQT8) · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9MAA7
- Every structure of UniProt Q9LQT8
- Elsewhere: RCSB PDB 2ZSH · PDBe 2ZSH · UniProt Q9MAA7 · UniProt Q9LQT8
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