MolNFT v1 · #56758 · protein

Crystal structure analysis of PDZ domain B

2ZPM · Regulator of sigma E protease: “Crystal structure analysis of PDZ domain B”. X-ray diffraction, 1 pocket (best druggability 0.36). MolNFT v1 #56758 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2ZPM
Type: protein
Length: 86 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Regulator of sigma E protease
EC: 3.4.24.-
UniProt: P0AEH1
Pockets: 1 · best druggability 0.36

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Regulator of sigma E protease (EC 3.4.24.-)	protein	86	16% helix, 37% strand	P0AEH1

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	66	0.36	0.77	12	empty

Modifications

Observed in the structure: 7 modified (methylation, engineered).

Compared structures

2ZPM · Crystal structure analysis of PDZ domain B · the same entry in another collection · chain A against A, TM-score 1.00
P0AEH1 · AlphaFold monomer V2.0 prediction for regulator of sigma-E protease rsep (P0AEH1) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0AEH1
Elsewhere: RCSB PDB 2ZPM · PDBe 2ZPM · UniProt P0AEH1

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