MolNFT v1 · #56731 · protein
Crystal structure of human F-spondin reeler domain (fragment 2)
2ZOU · Spondin-1: “Crystal structure of human F-spondin reeler domain (fragment 2)”. X-ray diffraction, 3 pockets (best druggability 0.64). MolNFT v1 #56731 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2ZOU
- Type
- protein
- Length
- 275 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spondin-1
- UniProt
- Q9HCB6
- Pockets
- 3 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Spondin-1 | protein | 135 | 2% helix, 46% strand | Q9HCB6 |
| B | Spondin-1 | protein | 140 | 2% helix, 43% strand | Q9HCB6 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 53 | 0.64 | 0.94 | 17 | empty |
| 2 | 80 | 0.33 | 0.75 | 12 | empty |
| 3 | 56 | 0.29 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 525 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HCB6
- Elsewhere: RCSB PDB 2ZOU · PDBe 2ZOU · UniProt Q9HCB6
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