MolNFT v1 · #56697 · protein
Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GLUR5, in complex with glutamate
2ZNS · Glutamate receptor, ionotropic kainate 1: “Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GLUR5, in complex…”. X-ray diffraction, 1 ligand (GLU), 3 pockets (best druggability 0.71). MolNFT…
- PDB
- 2ZNS
- Type
- protein
- Length
- 255 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor, ionotropic kainate 1
- UniProt
- P39086
- Ligands
- GLU
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor, ionotropic kainate 1 | protein | 255 | 39% helix, 22% strand | P39086 |
Ligands and binding sites
- GLU · Glutamic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 68 | 0.71 | 0.97 | 19 | GLU |
| 2 | 102 | 0.41 | 0.77 | 27 | empty |
| 3 | 50 | 0.37 | 0.80 | 15 | empty |
Compared structures
- 2ZNS · Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor… · the same entry in another collection · chain A against A, TM-score 1.00
- P39086 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, kainate 1 (P39086) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P39086
- Elsewhere: RCSB PDB 2ZNS · PDBe 2ZNS · UniProt P39086
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