MolNFT v1 · #56679 · protein

Crystal structure of ZN2+-bound form of alg-2

2ZN8 · Programmed cell death protein 6: “Crystal structure of ZN2+-bound form of alg-2”. X-ray diffraction, 2 ligands (ZN, NA), 2 pockets (best druggability 0.35). MolNFT v1 #56679 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 2ZN8
Type: protein
Length: 166 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Programmed cell death protein 6
UniProt: O75340
Ligands: ZN, NA
Pockets: 2 · best druggability 0.35

Structure

x-ray diffraction · 1 distinct chain · 58% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Programmed cell death protein 6	protein	166	58% helix, 5% strand	O75340

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A
NA · Sodium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	63	0.35	0.77	14	empty
2	72	0.30	0.72	19	empty

Compared structures

2ZN8 · Crystal structure of Zn2+-bound form of ALG-2 · the same entry in another collection · chain A against A, TM-score 1.00
O75340 · AlphaFold monomer V2.0 prediction for programmed cell death protein 6 (O75340) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75340
Elsewhere: RCSB PDB 2ZN8 · PDBe 2ZN8 · UniProt O75340

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