MolNFT v1 · #56649 · protein
Structure of 6-aminohexanoate-dimer hydrolase, G181D/H266N/D370Y mutant
2ZM0: “Structure of 6-aminohexanoate-dimer hydrolase, G181D/H266N/D370Y mutant”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.65). MolNFT v1 #56649 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2ZM0
- Type
- protein
- Length
- 384 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 6-aminohexanoate-dimer hydrolase
- EC
- 3.5.1.46
- UniProt
- P07061, P07062
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 6-aminohexanoate-dimer hydrolase (EC 3.5.1.46) | protein | 384 | 34% helix, 15% strand | P07061, P07062 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · 2 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 304 | 0.65 | 0.81 | 38 | MES, GOL |
| 2 | 192 | 0.45 | 0.74 | 29 | empty |
Compared structures
- 2ZM0 · Structure of 6-aminohexanoate-dimer hydrolase, G181D/H266N/D370Y mutant · the same entry in another collection · chain A against A, TM-score 1.00
- P07062 · AlphaFold monomer V2.0 prediction for 6-aminohexanoate-dimer hydrolase (P07062) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P07061 · AlphaFold monomer V2.0 prediction for 6-aminohexanoate-dimer hydrolase (P07061) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07061
- Every structure of UniProt P07062
- Elsewhere: RCSB PDB 2ZM0 · PDBe 2ZM0 · UniProt P07061 · UniProt P07062
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