MolNFT v1 · #56641 · protein
The structural basis for peptidomimetic inhibition of eukaryotic ribonucleotide reductase
2ZLF · Ribonucleoside-diphosphate reductase large chain 1: “The structural basis for peptidomimetic inhibition of eukaryotic ribonucleotide reductase”. X-ray diffraction, 3 pockets (best druggability 0.74). MolNFT v1 #56641 on GenesisL1…
- PDB
- 2ZLF
- Type
- protein
- Length
- 670 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribonucleoside-diphosphate reductase large chain 1; Ftldadf
- EC
- 1.17.4.1
- UniProt
- P21524
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribonucleoside-diphosphate reductase large chain 1 (EC 1.17.4.1) | protein | 663 | 46% helix, 12% strand | P21524 |
| B | Ftldadf | protein | 7 | 0% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 989 | 0.74 | 0.77 | 96 | empty |
| 2 | 97 | 0.38 | 0.75 | 15 | empty |
| 3 | 75 | 0.35 | 0.76 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 459 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2ZLF · The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase · the same entry in another collection · chain A against A, TM-score 1.00
- P21524 · AlphaFold monomer V2.0 prediction for ribonucleoside-diphosphate reductase large chain 1… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21524
- Elsewhere: RCSB PDB 2ZLF · PDBe 2ZLF · UniProt P21524
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