MolNFT v1 · #56618 · protein + RNA
Structural basis for dsrna recognition by NS1 protein of human influenza virus a
2ZKO · Non-structural protein 1: “Structural basis for dsrna recognition by NS1 protein of human influenza virus a”. X-ray diffraction, 5 pockets (best druggability 0.81). MolNFT v1 #56618 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2ZKO
- Type
- protein + RNA
- Length
- 182 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-structural protein 1; RNA (5'- R(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*UP*AP*UP*GP*CP*UP*GP*UP*…
- UniProt
- P03496
- Pockets
- 5 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 84% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Non-structural protein 1 | protein | 70 | 84% helix, 0% strand | P03496 |
| C, D | RNA (5'- R(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*UP*AP*UP*GP*CP*UP*GP*UP*CP*UP*UP*U)- 3') | rna | 21 | — | — |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A, B, D, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 175 | 0.81 | 0.97 | 27 | GOL |
| 2 | 51 | 0.67 | 0.97 | 12 | empty |
| 3 | 67 | 0.67 | 0.94 | 16 | empty |
| 4 | 594 | 0.64 | 0.76 | 27 | empty |
| 5 | 63 | 0.38 | 0.78 | 15 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1100 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 946 Ų buried · 93 hydrogen bonds · nucleic-nucleic
- A–C · 367 Ų buried · 2 hydrogen bonds · protein-nucleic
- B–D · 362 Ų buried · 2 hydrogen bonds · protein-nucleic
- A–D · 341 Ų buried · 8 hydrogen bonds · protein-nucleic
Compared structures
- 2ZKO · Structural basis for dsRNA recognition by NS1 protein of human influenza virus A · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03496
- Elsewhere: RCSB PDB 2ZKO · PDBe 2ZKO · UniProt P03496
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