MolNFT v1 · #56612 · protein
Human thrombopoietin neutralizing antibody TN1 Fab
2ZKH · Monoclonal TN1 Fab light chain: “Human thrombopoietin neutralizing antibody TN1 Fab”. X-ray diffraction, 2 pockets (best druggability 0.58). MolNFT v1 #56612 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2ZKH
- Type
- protein
- Length
- 419 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Monoclonal TN1 Fab light chain; Monoclonal TN1 Fab heavy chain
- Pockets
- 2 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Monoclonal TN1 Fab light chain | protein | 210 | 6% helix, 51% strand | — |
| H | Monoclonal TN1 Fab heavy chain | protein | 209 | 11% helix, 53% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 459 | 0.58 | 0.74 | 54 | empty |
| 2 | 99 | 0.38 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- L–H · 1681 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 2ZKH · Human thrombopoietin neutralizing antibody TN1 FAB · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2ZKH · PDBe 2ZKH
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.