MolNFT v1 · #56569 · protein

Archaeal DNA helicase hjm apo state in form 2

2ZJ8 · Putative SKI2-type helicase: “Archaeal DNA helicase hjm apo state in form 2”. X-ray diffraction, 5 pockets (best druggability 0.79). MolNFT v1 #56569 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2ZJ8
Type: protein
Length: 700 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative SKI2-type helicase
EC: 3.6.1.-
UniProt: O73946
Pockets: 5 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 54% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative SKI2-type helicase (EC 3.6.1.-)	protein	700	54% helix, 13% strand	O73946

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	606	0.79	0.85	81	empty
2	292	0.70	0.84	41	empty
3	120	0.47	0.78	16	empty
4	55	0.36	0.79	10	empty
5	54	0.36	0.79	22	empty

Compared structures

2ZJ8 · Archaeal DNA helicase Hjm apo state in form 2 · the same entry in another collection · chain A against A, TM-score 1.00
O73946 · AlphaFold monomer V2.0 prediction for ATP-dependent DNA helicase HEL308 (O73946) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O73946
Elsewhere: RCSB PDB 2ZJ8 · PDBe 2ZJ8 · UniProt O73946

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