MolNFT v1 · #56566 · protein

Archaeal DNA helicase hjm complexed with ADP in form 1

2ZJ5 · Putative SKI2-type helicase: “Archaeal DNA helicase hjm complexed with ADP in form 1”. X-ray diffraction, 2 ligands (ADP, SO4), 4 pockets (best druggability 0.77). MolNFT v1 #56566 on GenesisL1: 3D structure, binding sites and…

PDB: 2ZJ5
Type: protein
Length: 680 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative SKI2-type helicase
EC: 3.6.1.-
UniProt: O73946
Ligands: ADP, SO4
Pockets: 4 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative SKI2-type helicase (EC 3.6.1.-)	protein	680	52% helix, 13% strand	O73946

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
SO4 · Sulfate ion · ion · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1149	0.77	0.79	109	SO4, ADP
2	562	0.69	0.78	47	empty
3	82	0.37	0.76	16	empty
4	51	0.27	0.74	14	empty

Compared structures

2ZJ5 · Archaeal DNA helicase Hjm complexed with ADP in form 1 · the same entry in another collection · chain A against A, TM-score 1.00
O73946 · AlphaFold monomer V2.0 prediction for ATP-dependent DNA helicase HEL308 (O73946) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O73946
Elsewhere: RCSB PDB 2ZJ5 · PDBe 2ZJ5 · UniProt O73946

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