MolNFT v1 · #56563 · protein

Archaeal DNA helicase hjm apo state in form 1

2ZJ2 · Putative SKI2-type helicase: “Archaeal DNA helicase hjm apo state in form 1”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.78). MolNFT v1 #56563 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2ZJ2
Type: protein
Length: 653 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative SKI2-type helicase
EC: 3.6.1.-
UniProt: O73946
Ligands: SO4
Pockets: 4 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative SKI2-type helicase (EC 3.6.1.-)	protein	653	52% helix, 14% strand	O73946

Ligands and binding sites

SO4 · Sulfate ion · ion · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	673	0.78	0.83	72	empty
2	341	0.64	0.80	43	empty
3	184	0.42	0.73	22	SO4
4	68	0.34	0.76	15	empty

Compared structures

2ZJ2 · Archaeal DNA helicase Hjm apo state in form 1 · the same entry in another collection · chain A against A, TM-score 1.00
O73946 · AlphaFold monomer V2.0 prediction for ATP-dependent DNA helicase HEL308 (O73946) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O73946
Elsewhere: RCSB PDB 2ZJ2 · PDBe 2ZJ2 · UniProt O73946

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