MolNFT v1 · #5651 · protein
Crystal structure of pi class glutathione transferase
1EOG · Glutathione S-transferase: “Crystal structure of pi class glutathione transferase”. X-ray diffraction, 4 pockets (best druggability 0.74). MolNFT v1 #5651 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1EOG
- Type
- protein
- Length
- 416 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutathione S-transferase
- EC
- 2.5.1.18
- UniProt
- P09211
- Pockets
- 4 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 60% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Glutathione S-transferase (EC 2.5.1.18) | protein | 208 | 60% helix, 8% strand | P09211 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 753 | 0.74 | 0.79 | 94 | empty |
| 2 | 83 | 0.37 | 0.76 | 15 | empty |
| 3 | 66 | 0.32 | 0.75 | 16 | empty |
| 4 | 65 | 0.29 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1264 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 1EOG · Crystal structure of pi class glutathione transferase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09211
- Elsewhere: RCSB PDB 1EOG · PDBe 1EOG · UniProt P09211
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