MolNFT v1 · #56485 · protein

Crystal structure of agrocybe aegerita lectin aal mutant F93G

2ZGT · Anti-tumor lectin: “Crystal structure of agrocybe aegerita lectin aal mutant F93G”. X-ray diffraction, 3 pockets (best druggability 0.42). MolNFT v1 #56485 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2ZGT
Type: protein
Length: 281 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anti-tumor lectin
EC: 3.1.21.-
UniProt: Q6WY08
Pockets: 3 · best druggability 0.42

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 59% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Anti-tumor lectin (EC 3.1.21.-)	protein	140	0% helix, 59% strand	Q6WY08
B	Anti-tumor lectin (EC 3.1.21.-)	protein	141	0% helix, 60% strand	Q6WY08

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	84	0.42	0.79	23	empty
2	66	0.30	0.74	16	empty
3	57	0.28	0.74	12	empty

Interfaces

1 interface between chains.

A–B · 1055 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

2ZGT · Crystal structure of Agrocybe aegerita lectin AAL mutant F93G · the same entry in another collection · chain A against A, TM-score 1.00
Q6WY08 · AlphaFold monomer V2.0 prediction for anti-tumor lectin (Q6WY08) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6WY08
Elsewhere: RCSB PDB 2ZGT · PDBe 2ZGT · UniProt Q6WY08

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.