MolNFT v1 · #56443 · protein

Crystal structure of the KIF1A motor domain before mg release

2ZFI · Kinesin-like protein KIF1A, kinesin heavy chain isoform 5C: “Crystal structure of the KIF1A motor domain before mg release”. X-ray diffraction, 2 ligands (ADP, MG), 3 pockets (best druggability 0.61). MolNFT v1 #56443 on GenesisL1…

PDB: 2ZFI
Type: protein
Length: 329 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kinesin-like protein KIF1A, kinesin heavy chain isoform 5C
UniProt: P33173, P28738
Ligands: ADP, MG
Pockets: 3 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Kinesin-like protein KIF1A, kinesin heavy chain isoform 5C	protein	329	37% helix, 29% strand	P33173, P28738

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	175	0.61	0.83	24	empty
2	197	0.52	0.77	36	MG, ADP
3	96	0.37	0.75	19	empty

Compared structures

2ZFI · Crystal Structure of the Kif1A Motor Domain Before Mg Release · the same entry in another collection · chain A against A, TM-score 1.00
P33173 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF1A (P33173) · a predicted model of the same protein · chain A against A, TM-score 0.95
P28738 · AlphaFold monomer V2.0 prediction for kinesin heavy chain isoform 5C (P28738) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P33173
Every structure of UniProt P28738
Elsewhere: RCSB PDB 2ZFI · PDBe 2ZFI · UniProt P33173 · UniProt P28738

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.