MolNFT v1 · #56442 · protein

Crystal structure of putative CUTA1 from homo sapiens at 2.05A resolution

2ZFH: “Crystal structure of putative CUTA1 from homo sapiens at 2.05A resolution”. X-ray diffraction, 11 pockets (best druggability 0.78). MolNFT v1 #56442 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2ZFH
Type: protein
Length: 643 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cuta
UniProt: O60888
Pockets: 11 · best druggability 0.78

Structure

x-ray diffraction · 3 distinct chains · 34% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cuta	protein	109	33% helix, 41% strand	O60888
B, D, E, F	Cuta	protein	107	34% helix, 41% strand	O60888
C	Cuta	protein	106	35% helix, 42% strand	O60888

Pockets

11 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	464	0.78	0.86	80	empty
2	162	0.61	0.83	17	empty
3	281	0.61	0.79	50	empty
4	136	0.59	0.84	17	empty
5	144	0.52	0.80	18	empty

Interfaces

12 interfaces between chains.

D–E · 1227 Å² buried · 18 hydrogen bonds · protein-protein
B–C · 1218 Å² buried · 14 hydrogen bonds · protein-protein
A–B · 1200 Å² buried · 15 hydrogen bonds · protein-protein
E–F · 1173 Å² buried · 14 hydrogen bonds · protein-protein
D–F · 1161 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

2ZFH · Crystal structure of putative CutA1 from Homo sapiens at 2.05A resolution · the same entry in another collection · chain F against F, TM-score 1.00
O60888 · AlphaFold monomer V2.0 prediction for protein cuta (O60888) · a predicted model of the same protein · chain C against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O60888
Elsewhere: RCSB PDB 2ZFH · PDBe 2ZFH · UniProt O60888

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.