MolNFT v1 · #56345 · protein
Crystal structure of class C beta-lactamase act-1
2ZC7: “Crystal structure of class C beta-lactamase act-1”. X-ray diffraction, 11 pockets (best druggability 0.70). MolNFT v1 #56345 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2ZC7
- Type
- protein
- Length
- 1,436 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-lactamase act-1
- EC
- 3.5.2.6
- UniProt
- Q48428
- Pockets
- 11 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Beta-lactamase act-1 (EC 3.5.2.6) | protein | 359 | 39% helix, 22% strand | Q48428 |
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 570 | 0.70 | 0.79 | 70 | empty |
| 2 | 305 | 0.66 | 0.82 | 42 | empty |
| 3 | 337 | 0.66 | 0.81 | 48 | empty |
| 4 | 321 | 0.65 | 0.81 | 50 | empty |
| 5 | 298 | 0.54 | 0.75 | 38 | empty |
Interfaces
3 interfaces between chains.
- C–D · 282 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 230 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 203 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2ZC7 · Crystal Structure of Class C beta-Lactamase ACT-1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q48428
- Elsewhere: RCSB PDB 2ZC7 · PDBe 2ZC7 · UniProt Q48428
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