MolNFT v1 · #56240 · protein
Crystal structure of the Fab fragment of anti-ciguatoxin antibody 10C9
2Z91 · Anti-ciguatoxin antibody 10C9 Fab heavy chain: “Crystal structure of the Fab fragment of anti-ciguatoxin antibody 10C9”. X-ray diffraction, 6 pockets (best druggability 0.72). MolNFT v1 #56240 on GenesisL1: 3D structure, binding…
- PDB
- 2Z91
- Type
- protein
- Length
- 829 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti-ciguatoxin antibody 10C9 Fab heavy chain; Anti-ciguatoxin antibody 10C9 Fab light…
- Pockets
- 6 · best druggability 0.72
Structure
x-ray diffraction · 4 distinct chains · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Anti-ciguatoxin antibody 10C9 Fab heavy chain | protein | 207 | 7% helix, 53% strand | — |
| B | Anti-ciguatoxin antibody 10C9 Fab light chain | protein | 211 | 5% helix, 49% strand | — |
| C | Anti-ciguatoxin antibody 10C9 Fab heavy chain | protein | 203 | 6% helix, 54% strand | — |
| D | Anti-ciguatoxin antibody 10C9 Fab light chain | protein | 208 | 6% helix, 49% strand | — |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 984 | 0.72 | 0.76 | 109 | empty |
| 2 | 749 | 0.68 | 0.76 | 86 | empty |
| 3 | 95 | 0.52 | 0.83 | 24 | empty |
| 4 | 86 | 0.51 | 0.83 | 20 | empty |
| 5 | 171 | 0.47 | 0.76 | 30 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1833 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 1791 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 1191 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 2Z91 · Crystal structure of the Fab fragment of anti-ciguatoxin antibody 10C9 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2Z91 · PDBe 2Z91
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