MolNFT v1 · #56157 · protein

Crystal structure of human DAAM1 FH2

2Z6E · Disheveled-associated activator of morphogenesis 1: “Crystal structure of human DAAM1 FH2”. X-ray diffraction, 17 pockets (best druggability 0.64). MolNFT v1 #56157 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2Z6E
Type: protein
Length: 1,553 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Disheveled-associated activator of morphogenesis 1
UniProt: Q9Y4D1
Pockets: 17 · best druggability 0.64

Structure

x-ray diffraction · 4 distinct chains · 64% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Disheveled-associated activator of morphogenesis 1	protein	388	63% helix, 3% strand	Q9Y4D1
B	Disheveled-associated activator of morphogenesis 1	protein	396	65% helix, 3% strand	Q9Y4D1
C	Disheveled-associated activator of morphogenesis 1	protein	379	65% helix, 3% strand	Q9Y4D1
D	Disheveled-associated activator of morphogenesis 1	protein	390	65% helix, 3% strand	Q9Y4D1

Pockets

17 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	350	0.64	0.80	23	empty
2	316	0.60	0.78	40	empty
3	230	0.50	0.75	31	empty
4	256	0.50	0.74	33	empty
5	130	0.49	0.80	22	empty

Interfaces

6 interfaces between chains.

A–B · 5084 Å² buried · 70 hydrogen bonds · protein-protein
C–D · 5083 Å² buried · 62 hydrogen bonds · protein-protein
A–D · 288 Å² buried · 0 hydrogen bonds · protein-protein
B–C · 221 Å² buried · 0 hydrogen bonds · protein-protein
B–D · 62 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

2Z6E · Crystal Structure of Human DAAM1 FH2 · the same entry in another collection · chain D against D, TM-score 1.00
Q9Y4D1 · AlphaFold monomer V2.0 prediction for disheveled-associated activator of morphogenesis 1… · a predicted model of the same protein · chain C against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y4D1
Elsewhere: RCSB PDB 2Z6E · PDBe 2Z6E · UniProt Q9Y4D1

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