MolNFT v1 · #56122 · protein
Human sulfotransferase SULT1B1 in complex with pap
2Z5F · Sulfotransferase family cytosolic 1B member 1: “Human sulfotransferase SULT1B1 in complex with pap”. X-ray diffraction, 1 ligand (A3P), 4 pockets (best druggability 0.85). MolNFT v1 #56122 on GenesisL1: 3D structure, binding sites…
- PDB
- 2Z5F
- Type
- protein
- Length
- 586 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sulfotransferase family cytosolic 1B member 1
- EC
- 2.8.2.-
- UniProt
- O43704
- Ligands
- A3P
- Pockets
- 4 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Sulfotransferase family cytosolic 1B member 1 (EC 2.8.2.-) | protein | 293 | 43% helix, 11% strand | O43704 |
Ligands and binding sites
- A3P · Adenosine-3'-5'-diphosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 307 | 0.85 | 0.95 | 54 | A3P |
| 2 | 326 | 0.85 | 0.94 | 55 | A3P |
| 3 | 617 | 0.72 | 0.80 | 70 | empty |
| 4 | 57 | 0.35 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 625 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43704
- Elsewhere: RCSB PDB 2Z5F · PDBe 2Z5F · UniProt O43704
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