MolNFT v1 · #56118 · protein
Crystal structure of a novel chaperone complex for yeast 20S proteasome assembly
2Z5B · Protein YPL144W: “Crystal structure of a novel chaperone complex for yeast 20S proteasome assembly”. X-ray diffraction, 2 pockets (best druggability 0.46). MolNFT v1 #56118 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2Z5B
- Type
- protein
- Length
- 259 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein YPL144W; Uncharacterized protein YLR021W
- UniProt
- Q12245, Q07951
- Pockets
- 2 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein YPL144W | protein | 127 | 31% helix, 37% strand | Q12245 |
| B | Uncharacterized protein YLR021W | protein | 132 | 32% helix, 33% strand | Q07951 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.46 | 0.81 | 20 | empty |
| 2 | 50 | 0.27 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1176 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 2Z5B · Crystal Structure of a Novel Chaperone Complex for Yeast 20S Proteasome Assembly · the same entry in another collection · chain A against A, TM-score 1.00
- Q12245 · AlphaFold monomer V2.0 prediction for proteasome chaperone 4 (Q12245) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q07951 · AlphaFold monomer V2.0 prediction for proteasome chaperone 3 (Q07951) · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12245
- Every structure of UniProt Q07951
- Elsewhere: RCSB PDB 2Z5B · PDBe 2Z5B · UniProt Q12245 · UniProt Q07951
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