MolNFT v1 · #56098 · protein
Crystal structure of a murine antibody Fab 528
2Z4Q · Anti EGFR antibody Fab, light chain: “Crystal structure of a murine antibody Fab 528”. X-ray diffraction, 2 ligands (CD, CL), 5 pockets (best druggability 0.64). MolNFT v1 #56098 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 2Z4Q
- Type
- protein
- Length
- 437 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti EGFR antibody Fab, light chain; Anti EGFR antibody Fab, heavy chain
- Ligands
- CD, CL
- Pockets
- 5 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Anti EGFR antibody Fab, light chain | protein | 219 | 6% helix, 52% strand | — |
| B | Anti EGFR antibody Fab, heavy chain | protein | 218 | 6% helix, 51% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 680 | 0.64 | 0.74 | 66 | empty |
| 2 | 126 | 0.43 | 0.76 | 27 | empty |
| 3 | 98 | 0.38 | 0.75 | 23 | empty |
| 4 | 74 | 0.33 | 0.75 | 16 | empty |
| 5 | 77 | 0.30 | 0.73 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1923 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 2Z4Q · Crystal structure of a murine antibody FAB 528 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2Z4Q · PDBe 2Z4Q
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.