MolNFT v1 · #56084 · protein

Crystal structure of native-ORF134

2Z46: “Crystal structure of native-ORF134”. X-ray diffraction, 4 pockets (best druggability 0.46). MolNFT v1 #56084 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2Z46
Type: protein
Length: 658 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ORF134
UniProt: Q44177
Pockets: 4 · best druggability 0.46

Structure

x-ray diffraction · 5 distinct chains · 85% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	ORF134	protein	109	88% helix, 0% strand	Q44177
C	ORF134	protein	109	86% helix, 0% strand	Q44177
D	ORF134	protein	110	86% helix, 0% strand	Q44177
E	ORF134	protein	110	83% helix, 0% strand	Q44177
F	ORF134	protein	111	81% helix, 0% strand	Q44177

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	168	0.46	0.76	20	empty
2	101	0.39	0.75	13	empty
3	85	0.35	0.75	14	empty
4	57	0.30	0.76	16	empty

Interfaces

6 interfaces between chains.

C–D · 2712 Å² buried · 25 hydrogen bonds · protein-protein
E–F · 2693 Å² buried · 22 hydrogen bonds · protein-protein
A–B · 2626 Å² buried · 29 hydrogen bonds · protein-protein
A–D · 293 Å² buried · 2 hydrogen bonds · protein-protein
B–D · 236 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

2Z46 · Crystal Structure of Native-ORF134 · the same entry in another collection · chain F against F, TM-score 1.00
Q44177 · AlphaFold monomer V2.0 prediction for rubisco chaperone rbcx (Q44177) · a predicted model of the same protein · chain C against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q44177
Elsewhere: RCSB PDB 2Z46 · PDBe 2Z46 · UniProt Q44177

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.