MolNFT v1 · #56053 · protein
Crystal structure of bacillus subtilis codw, a non-canonical hslv-like peptidase with an impaired catalytic apparatus
2Z3A · ATP-dependent protease hslv: “Crystal structure of bacillus subtilis codw, a non-canonical hslv-like peptidase with an impaired catalytic…”. X-ray diffraction, 20 pockets (best druggability 0.79). MolNFT v1 #56053 on GenesisL1: 3D…
- PDB
- 2Z3A
- Type
- protein
- Length
- 2,160 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent protease hslv
- EC
- 3.4.25.-
- UniProt
- P39070
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | ATP-dependent protease hslv (EC 3.4.25.-) | protein | 180 | 34% helix, 28% strand | P39070 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1043 | 0.79 | 0.81 | 160 | empty |
| 2 | 737 | 0.73 | 0.79 | 86 | empty |
| 3 | 507 | 0.72 | 0.81 | 78 | empty |
| 4 | 284 | 0.63 | 0.80 | 46 | empty |
| 5 | 266 | 0.63 | 0.81 | 55 | empty |
Interfaces
24 interfaces between chains.
- A–F · 880 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 856 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 846 Ų buried · 13 hydrogen bonds · protein-protein
- I–J · 846 Ų buried · 9 hydrogen bonds · protein-protein
- E–F · 846 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 2Z3A · Crystal Structure of Bacillus Subtilis CodW, a non-canonical HslV-like peptidase with an… · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P39070
- Elsewhere: RCSB PDB 2Z3A · PDBe 2Z3A · UniProt P39070
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