MolNFT v1 · #56047 · protein
Crystal structure of SPCIA1/ASF1 complex with HIP1
2Z34 · Histone chaperone CIA1: “Crystal structure of SPCIA1/ASF1 complex with HIP1”. X-ray diffraction, 3 pockets (best druggability 0.75). MolNFT v1 #56047 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2Z34
- Type
- protein
- Length
- 347 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone chaperone CIA1; Protein HIR1
- UniProt
- O74515, P87314
- Pockets
- 3 · best druggability 0.75
Structure
x-ray diffraction · 4 distinct chains · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone chaperone CIA1 | protein | 155 | 6% helix, 50% strand | O74515 |
| B | Histone chaperone CIA1 | protein | 149 | 7% helix, 52% strand | O74515 |
| C | Protein HIR1 | protein | 21 | 0% helix, 48% strand | P87314 |
| D | Protein HIR1 | protein | 22 | 0% helix, 45% strand | P87314 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 381 | 0.75 | 0.86 | 57 | empty |
| 2 | 217 | 0.57 | 0.80 | 38 | empty |
| 3 | 80 | 0.36 | 0.76 | 16 | empty |
Interfaces
6 interfaces between chains.
- A–B · 844 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 748 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 733 Ų buried · 16 hydrogen bonds · protein-protein
- A–D · 253 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 249 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2Z34 · Crystal structure of SpCia1/Asf1 complex with Hip1 · the same entry in another collection · chain D against D, TM-score 1.00
- O74515 · AlphaFold monomer V2.0 prediction for histone chaperone CIA1 (O74515) · a predicted model of the same protein · chain B against A, TM-score 0.93
- P87314 · AlphaFold monomer V2.0 prediction for protein HIR1 (P87314) · a predicted model of the same protein · chain D against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O74515
- Every structure of UniProt P87314
- Elsewhere: RCSB PDB 2Z34 · PDBe 2Z34 · UniProt O74515 · UniProt P87314
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