MolNFT v1 · #55986 · protein
Crystal structure of 5-aminolevulinic acid dehydratase (alad) from mus musculs
2Z1B · Delta-aminolevulinic acid dehydratase: “Crystal structure of 5-aminolevulinic acid dehydratase (alad) from mus musculs”. X-ray diffraction, 14 pockets (best druggability 0.78). MolNFT v1 #55986 on GenesisL1: 3D structure, binding…
- PDB
- 2Z1B
- Type
- protein
- Length
- 1,194 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Delta-aminolevulinic acid dehydratase
- EC
- 4.2.1.24
- UniProt
- Q9DD05
- Pockets
- 14 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 39% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Delta-aminolevulinic acid dehydratase (EC 4.2.1.24) | protein | 290 | 41% helix, 14% strand | Q9DD05 |
| B | Delta-aminolevulinic acid dehydratase (EC 4.2.1.24) | protein | 320 | 36% helix, 15% strand | Q9DD05 |
| C | Delta-aminolevulinic acid dehydratase (EC 4.2.1.24) | protein | 288 | 39% helix, 15% strand | Q9DD05 |
| D | Delta-aminolevulinic acid dehydratase (EC 4.2.1.24) | protein | 296 | 40% helix, 13% strand | Q9DD05 |
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 700 | 0.78 | 0.83 | 72 | empty |
| 2 | 192 | 0.71 | 0.88 | 40 | empty |
| 3 | 536 | 0.69 | 0.78 | 57 | empty |
| 4 | 336 | 0.60 | 0.77 | 36 | empty |
| 5 | 310 | 0.60 | 0.78 | 37 | empty |
Interfaces
5 interfaces between chains.
- A–B · 2629 Ų buried · 33 hydrogen bonds · protein-protein
- C–D · 2569 Ų buried · 26 hydrogen bonds · protein-protein
- B–C · 1629 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 242 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 173 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2Z1B · Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculs · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9DD05
- Elsewhere: RCSB PDB 2Z1B · PDBe 2Z1B · UniProt Q9DD05
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