MolNFT v1 · #55921 · protein

Crystal structure of kinase domain of human 5'-AMP-activated protein kinase alpha-2 subunit mutant (T172D)

2YZA · 5'-AMP-activated protein kinase catalytic subunit alpha-2: “Crystal structure of kinase domain of human 5'-AMP-activated protein kinase alpha-2 subunit mutant (T172D)”. X-ray diffraction, 2 pockets (best druggability 0.77). MolNFT…

PDB: 2YZA
Type: protein
Length: 258 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-AMP-activated protein kinase catalytic subunit alpha-2
EC: 2.7.11.1
UniProt: P54646
Pockets: 2 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1)	protein	258	40% helix, 18% strand	P54646

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	407	0.77	0.86	46	empty
2	85	0.33	0.74	14	empty

Compared structures

2YZA · Crystal structure of kinase domain of Human 5'-AMP-activated protein kinase alpha-2… · the same entry in another collection · chain A against A, TM-score 1.00
P54646 · AlphaFold monomer V2.0 prediction for 5'-AMP-activated protein kinase catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P54646
Elsewhere: RCSB PDB 2YZA · PDBe 2YZA · UniProt P54646

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