MolNFT v1 · #55914 · protein

Crystal structure of the ligand-binding domain of murine shps-1/SIRP alpha

2YZ1 · Tyrosine-protein phosphatase non-receptor type substrate 1: “Crystal structure of the ligand-binding domain of murine shps-1/SIRP alpha”. X-ray diffraction, 2 pockets (best druggability 0.72). MolNFT v1 #55914 on GenesisL1: 3D…

PDB: 2YZ1
Type: protein
Length: 228 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein phosphatase non-receptor type substrate 1
UniProt: P97797
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Tyrosine-protein phosphatase non-receptor type substrate 1	protein	114	3% helix, 45% strand	P97797

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	355	0.72	0.84	54	empty
2	129	0.38	0.74	24	empty

Interfaces

1 interface between chains.

A–B · 1435 Å² buried · 27 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2YZ1 · Crystal structure of the ligand-binding domain of murine SHPS-1/SIRP alpha · the same entry in another collection · chain A against A, TM-score 1.00
P97797 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type… · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P97797
Elsewhere: RCSB PDB 2YZ1 · PDBe 2YZ1 · UniProt P97797

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.