MolNFT v1 · #55268 · protein
Complex of a B21 chicken MHC class I molecule and a 10MER chicken peptide
2YEZ · Major histocompatibility complex class I glycoprotein…: “Complex of a B21 chicken MHC class I molecule and a 10MER chicken peptide”. X-ray diffraction, 2 pockets (best druggability 0.67). MolNFT v1 #55268 on GenesisL1: 3D structure…
- PDB
- 2YEZ
- Type
- protein
- Length
- 384 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Major histocompatibility complex class I glycoprotein haplotype B21…
- UniProt
- Q95601, P21611, Q5ZMD1
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 22% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Major histocompatibility complex class I glycoprotein haplotype B21 | protein | 278 | 28% helix, 38% strand | Q95601 |
| B | Beta-2-microglobulin | protein | 96 | 0% helix, 50% strand | P21611 |
| C | 14-3-3 protein theta | protein | 10 | 40% helix, 0% strand | Q5ZMD1 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 526 | 0.67 | 0.78 | 61 | empty |
| 2 | 64 | 0.31 | 0.75 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1632 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 940 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 2YEZ · Complex of a B21 chicken MHC class I molecule and a 10MER chicken peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P21611 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P21611) · a predicted model of the same protein · chain B against A, TM-score 0.95
- Q5ZMD1 · AlphaFold monomer V2.0 prediction for 14-3-3 protein theta (Q5ZMD1) · a predicted model of the same protein · chain C against A, TM-score 0.42
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q95601
- Every structure of UniProt P21611
- Every structure of UniProt Q5ZMD1
- Elsewhere: RCSB PDB 2YEZ · PDBe 2YEZ · UniProt Q95601 · UniProt P21611 · UniProt Q5ZMD1
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