MolNFT v1 · #55095 · protein
PEX4P-PEX22P mutant II structure
2Y9P · Ubiquitin-conjugating enzyme E2-21 kda: “PEX4P-PEX22P mutant II structure”. X-ray diffraction, 1 pocket (best druggability 0.31). MolNFT v1 #55095 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2Y9P
- Type
- protein
- Length
- 290 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-conjugating enzyme E2-21 kda; Peroxisome assembly protein 22
- EC
- 6.3.2.19
- UniProt
- P29340, P39718
- Pockets
- 1 · best druggability 0.31
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-conjugating enzyme E2-21 kda (EC 6.3.2.19) | protein | 166 | 35% helix, 18% strand | P29340 |
| B | Peroxisome assembly protein 22 | protein | 124 | 40% helix, 18% strand | P39718 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 63 | 0.31 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 781 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 2Y9P · Pex4p-Pex22p mutant II structure · the same entry in another collection · chain A against A, TM-score 1.00
- P29340 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2-21 kda (P29340) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P39718 · AlphaFold monomer V2.0 prediction for peroxisome assembly protein 22 (P39718) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29340
- Every structure of UniProt P39718
- Elsewhere: RCSB PDB 2Y9P · PDBe 2Y9P · UniProt P29340 · UniProt P39718
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