MolNFT v1 · #5509 · protein
Structure of human udp-galactose 4-epimerase in complex with NAD+
1EK5: “Structure of human udp-galactose 4-epimerase in complex with NAD+”. X-ray diffraction, 1 ligand (NAD), 1 pocket (best druggability 0.84). MolNFT v1 #5509 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1EK5
- Type
- protein
- Length
- 346 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Udp-galactose 4-epimerase
- EC
- 5.1.3.2
- UniProt
- Q14376
- Ligands
- NAD
- Pockets
- 1 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Udp-galactose 4-epimerase (EC 5.1.3.2) | protein | 346 | 40% helix, 18% strand | Q14376 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 986 | 0.84 | 0.85 | 110 | NAD |
Compared structures
- 1EK5 · Structure of human udp-galactose 4-epimerase in complex with NAD+ · the same entry in another collection · chain A against A, TM-score 1.00
- Q14376 · AlphaFold monomer V2.0 prediction for udp-glucose 4-epimerase (Q14376) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14376
- Elsewhere: RCSB PDB 1EK5 · PDBe 1EK5 · UniProt Q14376
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