MolNFT v1 · #54944 · protein

Solution structure of human ubiquitin conjugating enzyme RAD6B

2Y4W · Ubiquitin-conjugating enzyme E2 B: “Solution structure of human ubiquitin conjugating enzyme RAD6B”. Solution nmr, 3 pockets (best druggability 0.66). MolNFT v1 #54944 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2Y4W
Type: protein
Length: 152 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin-conjugating enzyme E2 B
EC: 6.3.2.19
UniProt: P63146
Pockets: 3 · best druggability 0.66

Structure

solution nmr · 1 distinct chain · 35% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin-conjugating enzyme E2 B (EC 6.3.2.19)	protein	152	35% helix, 14% strand	P63146

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	176	0.66	0.86	24	empty
2	91	0.50	0.82	27	empty
3	52	0.33	0.78	11	empty

Compared structures

2Y4W · Solution structure of human ubiquitin conjugating enzyme Rad6b · the same entry in another collection · chain A against A, TM-score 1.00
P63146 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 B (P63146) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63146
Elsewhere: RCSB PDB 2Y4W · PDBe 2Y4W · UniProt P63146

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