MolNFT v1 · #5492 · protein
Fab fragment of neutralising monoclonal antibody 4C4 complexed with G- H loop from fmdv.
1EJO · IGG2A monoclonal antibody (light chain): “Fab fragment of neutralising monoclonal antibody 4C4 complexed with G- H loop from fmdv.”. X-ray diffraction, 3 pockets (best druggability 0.61). MolNFT v1 #5492 on GenesisL1: 3D structure…
- PDB
- 1EJO
- Type
- protein
- Length
- 443 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IGG2A monoclonal antibody (light chain); IGG2A monoclonal antibody (heavy chain); Fmdv…
- Pockets
- 3 · best druggability 0.61
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | IGG2A monoclonal antibody (light chain) | protein | 216 | 6% helix, 53% strand | — |
| H | IGG2A monoclonal antibody (heavy chain) | protein | 214 | 6% helix, 48% strand | — |
| P | Fmdv peptide | protein | 13 | 0% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 437 | 0.61 | 0.76 | 50 | empty |
| 2 | 89 | 0.36 | 0.75 | 20 | empty |
| 3 | 55 | 0.27 | 0.74 | 16 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1798 Ų buried · 19 hydrogen bonds · protein-protein
- L–P · 444 Ų buried · 6 hydrogen bonds · protein-protein
- H–P · 398 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 1EJO · Fab fragment of neutralising monoclonal antibody 4C4 complexed with G-H loop from fmdv. · the same entry in another collection · chain P against P, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1EJO · PDBe 1EJO
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