MolNFT v1 · #54778 · protein
Structural basis for amsh-escrt-III CHMP3 interaction
2XZE · Stam-binding protein: “Structural basis for amsh-escrt-III CHMP3 interaction”. X-ray diffraction, 3 pockets (best druggability 0.67). MolNFT v1 #54778 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2XZE
- Type
- protein
- Length
- 322 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Stam-binding protein; Charged multivesicular body protein 3
- EC
- 3.4.19.-
- UniProt
- O95630, Q9Y3E7
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 4 distinct chains · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Stam-binding protein (EC 3.4.19.-) | protein | 141 | 74% helix, 0% strand | O95630 |
| B | Stam-binding protein (EC 3.4.19.-) | protein | 138 | 76% helix, 0% strand | O95630 |
| Q | Charged multivesicular body protein 3 | protein | 23 | 87% helix, 0% strand | Q9Y3E7 |
| R | Charged multivesicular body protein 3 | protein | 20 | 80% helix, 0% strand | Q9Y3E7 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 360 | 0.67 | 0.81 | 39 | empty |
| 2 | 206 | 0.50 | 0.76 | 30 | empty |
| 3 | 92 | 0.35 | 0.75 | 17 | empty |
Interfaces
5 interfaces between chains.
- A–Q · 928 Ų buried · 15 hydrogen bonds · protein-protein
- B–R · 866 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 344 Ų buried · 1 hydrogen bond · protein-protein
- A–R · 222 Ų buried · 1 hydrogen bond · protein-protein
- B–Q · 93 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2XZE · Structural basis for AMSH-ESCRT-III CHMP3 interaction · the same entry in another collection · chain R against R, TM-score 1.00
- O95630 · AlphaFold monomer V2.0 prediction for stam-binding protein (O95630) · a predicted model of the same protein · chain B against A, TM-score 0.96
- Q9Y3E7 · AlphaFold monomer V2.0 prediction for charged multivesicular body protein 3 (Q9Y3E7) · a predicted model of the same protein · chain Q against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95630
- Every structure of UniProt Q9Y3E7
- Elsewhere: RCSB PDB 2XZE · PDBe 2XZE · UniProt O95630 · UniProt Q9Y3E7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.