MolNFT v1 · #54684 · protein
Siap R147E mutant in complex with sialylamide
2XWO · Sialic acid-binding periplasmic protein siap: “Siap R147E mutant in complex with sialylamide”. X-ray diffraction, 1 ligand (SLM), 1 pocket (best druggability 0.79). MolNFT v1 #54684 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2XWO
- Type
- protein
- Length
- 308 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sialic acid-binding periplasmic protein siap
- UniProt
- P44542
- Ligands
- SLM
- Pockets
- 1 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sialic acid-binding periplasmic protein siap | protein | 308 | 53% helix, 19% strand | P44542 |
Ligands and binding sites
- SLM · (2S,4S,5R,6R)-5-acetamido-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 243 | 0.79 | 0.92 | 43 | SLM |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P44542
- Elsewhere: RCSB PDB 2XWO · PDBe 2XWO · UniProt P44542
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