MolNFT v1 · #54369 · protein
High resolution snapshots of defined tolc open states present an iris- like movement of periplasmic entrance helices
2XMN · Outer membrane protein tolc: “High resolution snapshots of defined tolc open states present an iris- like movement of periplasmic entrance…”. X-ray diffraction, 1 ligand (CL), 12 pockets (best druggability 0.51). MolNFT v1 #54369 on…
- PDB
- 2XMN
- Type
- protein
- Length
- 1,284 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Outer membrane protein tolc
- UniProt
- P02930
- Ligands
- CL
- Pockets
- 12 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 64% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Outer membrane protein tolc | protein | 428 | 64% helix, 16% strand | P02930 |
Ligands and binding sites
- CL · Chloride ion · ion · 3 copies · chains A, B, C
- LMT · Dodecyl-beta-D-maltoside · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 233 | 0.51 | 0.76 | 37 | empty |
| 2 | 211 | 0.48 | 0.75 | 34 | empty |
| 3 | 206 | 0.48 | 0.75 | 27 | empty |
| 4 | 139 | 0.45 | 0.76 | 22 | empty |
| 5 | 132 | 0.43 | 0.76 | 22 | empty |
Interfaces
3 interfaces between chains.
- B–C · 2392 Ų buried · 53 hydrogen bonds · protein-protein
- A–B · 2351 Ų buried · 52 hydrogen bonds · protein-protein
- A–C · 2348 Ų buried · 51 hydrogen bonds · protein-protein
Compared structures
- 2XMN · High resolution snapshots of defined TolC open states present an iris- like movement of… · the same entry in another collection · chain A against A, TM-score 1.00
- P02930 · AlphaFold monomer V2.0 prediction for outer membrane protein tolc (P02930) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02930
- Elsewhere: RCSB PDB 2XMN · PDBe 2XMN · UniProt P02930
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.