MolNFT v1 · #54332 · protein + RNA

Crystal structure of the CSY4-crrna complex, hexagonal form

2XLJ · CSY4 endoribonuclease: “Crystal structure of the CSY4-crrna complex, hexagonal form”. X-ray diffraction, 6 pockets (best druggability 0.60). MolNFT v1 #54332 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2XLJ
Type: protein + RNA
Length: 193 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CSY4 endoribonuclease; 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3'
UniProt: A3KUJ4
Pockets: 6 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CSY4 endoribonuclease	protein	178	23% helix, 26% strand	A3KUJ4
B	5'-R(CPUPGPCPCPGPUPAPUPAPGPGPCPADGC)-3'	rna	15	—	—

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	107	0.60	0.87	24	empty
2	67	0.43	0.82	17	empty
3	75	0.40	0.79	16	empty
4	73	0.37	0.78	16	empty
5	64	0.36	0.77	14	empty

Interfaces

1 interface between chains.

A–B · 988 Å² buried · 22 hydrogen bonds · protein-nucleic

Compared structures

2XLJ · Crystal structure of the Csy4-crRNA complex, hexagonal form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A3KUJ4
Elsewhere: RCSB PDB 2XLJ · PDBe 2XLJ · UniProt A3KUJ4

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