MolNFT v1 · #54328 · protein
Structure and metal-loading of a soluble periplasm cupro-protein: apo-cuca-closed (semet)
2XLF · SLL1785 protein: “Structure and metal-loading of a soluble periplasm cupro-protein: apo-cuca-closed (semet)”. X-ray diffraction, 5 pockets (best druggability 0.74). MolNFT v1 #54328 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2XLF
- Type
- protein
- Length
- 932 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SLL1785 protein
- UniProt
- P73600
- Pockets
- 5 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 18% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | SLL1785 protein | protein | 233 | 18% helix, 36% strand | P73600 |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 462 | 0.74 | 0.83 | 85 | empty |
| 2 | 686 | 0.74 | 0.80 | 57 | empty |
| 3 | 597 | 0.74 | 0.81 | 54 | empty |
| 4 | 141 | 0.62 | 0.85 | 26 | empty |
| 5 | 72 | 0.39 | 0.79 | 21 | empty |
Interfaces
5 interfaces between chains.
- A–B · 959 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 959 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 345 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 320 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 294 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 32 modified, 4 disulfide (engineered, disulfide).
Compared structures
- 2XLF · Structure and metal-loading of a soluble periplasm cupro-protein: apo- CucA-closed (SeMet) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P73600
- Elsewhere: RCSB PDB 2XLF · PDBe 2XLF · UniProt P73600
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