MolNFT v1 · #54309 · protein

Prion-like conversion during amyloid formation at atomic resolution

2XKS · Beta-2-microglobulin: “Prion-like conversion during amyloid formation at atomic resolution”. Solution nmr, 1 pocket (best druggability 0.34). MolNFT v1 #54309 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2XKS
Type: protein
Length: 99 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-2-microglobulin
UniProt: P61769
Pockets: 1 · best druggability 0.34

Structure

solution nmr · 1 distinct chain · 0% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-2-microglobulin	protein	99	0% helix, 38% strand	P61769

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	62	0.34	0.77	14	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2XKS · Prion-like conversion during amyloid formation at atomic resolution · the same entry in another collection · chain A against A, TM-score 1.00
P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61769
Elsewhere: RCSB PDB 2XKS · PDBe 2XKS · UniProt P61769

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.