MolNFT v1 · #54194 · protein

Crystal structure of the UNC18-syntaxin 1 complex from monosiga brevicollis

2XHE: “Crystal structure of the UNC18-syntaxin 1 complex from monosiga brevicollis”. X-ray diffraction, 15 pockets (best druggability 0.70). MolNFT v1 #54194 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2XHE
Type: protein
Length: 786 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: UNC18; SYNTAXIN1
UniProt: A9V0L3, A9UTG5
Pockets: 15 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 53% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	UNC18	protein	566	46% helix, 15% strand	A9V0L3
B	SYNTAXIN1	protein	220	70% helix, 0% strand	A9UTG5

Pockets

15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	339	0.70	0.83	34	empty
2	514	0.68	0.78	45	empty
3	191	0.60	0.82	27	empty
4	283	0.59	0.78	36	empty
5	258	0.56	0.77	31	empty

Interfaces

1 interface between chains.

A–B · 2445 Å² buried · 27 hydrogen bonds · protein-protein

Compared structures

2XHE · Crystal structure of the Unc18-syntaxin 1 complex from Monosiga brevicollis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A9V0L3
Every structure of UniProt A9UTG5
Elsewhere: RCSB PDB 2XHE · PDBe 2XHE · UniProt A9V0L3 · UniProt A9UTG5

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