MolNFT v1 · #54165 · protein
The X-ray structure of the escherichia COLI colicin M immunity protein demonstrates the presence of a disulphide bridge, which is functionally essential
2XGL · Colicin-M immunity protein: “The X-ray structure of the escherichia COLI colicin M immunity protein demonstrates the presence of a…”. X-ray diffraction, 3 ligands (NA, CD, CL), 1 pocket (best druggability 0.40). MolNFT v1 #54165 on…
- PDB
- 2XGL
- Type
- protein
- Length
- 180 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Colicin-M immunity protein
- UniProt
- P18002
- Ligands
- NA, CD, CL
- Pockets
- 1 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Colicin-M immunity protein | protein | 91 | 32% helix, 26% strand | P18002 |
| B | Colicin-M immunity protein | protein | 89 | 36% helix, 28% strand | P18002 |
Ligands and binding sites
- NA · Sodium ion · metal · 14 copies · chains A, B
- CD · Cadmium ion · metal · 7 copies · chains A, B
- CL · Chloride ion · ion · 11 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 143 | 0.40 | 0.74 | 24 | CL, NA |
Interfaces
1 interface between chains.
- A–B · 306 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 2XGL · The X-ray structure of the Escherichia coli colicin M immunity protein demonstrates the… · the same entry in another collection · chain A against A, TM-score 1.00
- P18002 · AlphaFold monomer V2.0 prediction for colicin-M immunity protein (P18002) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18002
- Elsewhere: RCSB PDB 2XGL · PDBe 2XGL · UniProt P18002
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