MolNFT v1 · #54153 · protein
Structural basis of gene regulation by protein pii: the crystal complex of pii and pipx from synechococcus elongatus pcc 7942
2XG8 · Nitrogen regulatory protein P-II: “Structural basis of gene regulation by protein pii: the crystal complex of pii and pipx from synechococcus…”. X-ray diffraction, 9 pockets (best druggability 0.84). MolNFT v1 #54153 on GenesisL1…
- PDB
- 2XG8
- Type
- protein
- Length
- 578 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nitrogen regulatory protein P-II; Pipx
- UniProt
- P0A3F4, Q7X386
- Pockets
- 9 · best druggability 0.84
Structure
x-ray diffraction · 5 distinct chains · 27% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nitrogen regulatory protein P-II | protein | 106 | 24% helix, 42% strand | P0A3F4 |
| B | Nitrogen regulatory protein P-II | protein | 108 | 23% helix, 39% strand | P0A3F4 |
| C | Nitrogen regulatory protein P-II | protein | 112 | 22% helix, 38% strand | P0A3F4 |
| D, E | Pipx | protein | 87 | 37% helix, 34% strand | Q7X386 |
| F | Pipx | protein | 78 | 31% helix, 32% strand | Q7X386 |
Pockets
9 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 925 | 0.84 | 0.85 | 97 | empty |
| 2 | 461 | 0.72 | 0.82 | 45 | empty |
| 3 | 51 | 0.68 | 0.97 | 21 | empty |
| 4 | 319 | 0.64 | 0.80 | 35 | empty |
| 5 | 284 | 0.62 | 0.80 | 33 | empty |
Interfaces
12 interfaces between chains.
- A–B · 1149 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 1146 Ų buried · 24 hydrogen bonds · protein-protein
- B–C · 1119 Ų buried · 22 hydrogen bonds · protein-protein
- A–E · 538 Ų buried · 5 hydrogen bonds · protein-protein
- C–F · 526 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2XG8 · Structural basis of gene regulation by protein PII: The crystal complex of PII and PipX… · the same entry in another collection · chain F against F, TM-score 1.00
- P0A3F4 · AlphaFold monomer V2.0 prediction for nitrogen regulatory protein P-II (P0A3F4) · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A3F4
- Every structure of UniProt Q7X386
- Elsewhere: RCSB PDB 2XG8 · PDBe 2XG8 · UniProt P0A3F4 · UniProt Q7X386
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