MolNFT v1 · #53857 · protein

Structure of human serine-arginine-rich protein-specific kinase 2 (SRPK2) bound to purvalanol B

2X7G · Uncharacterized protein SRPK2: “Structure of human serine-arginine-rich protein-specific kinase 2 (SRPK2) bound to purvalanol B”. X-ray diffraction, 2 ligands (PVB, SO4), 3 pockets (best druggability 0.75). MolNFT v1 #53857 on…

PDB: 2X7G
Type: protein
Length: 344 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uncharacterized protein SRPK2
EC: 2.7.11.1
UniProt: C9JQJ0
Ligands: PVB, SO4
Pockets: 3 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uncharacterized protein SRPK2 (EC 2.7.11.1)	protein	344	43% helix, 17% strand	C9JQJ0

Ligands and binding sites

PVB · Purvalanol B · ligand · chains A
SO4 · Sulfate ion · ion · 7 copies · chains A
EDO · 1,2-ethanediol · additive · 6 copies · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	658	0.75	0.81	52	PVB, SO4, EDO
2	103	0.46	0.79	16	EDO
3	55	0.31	0.76	13	empty

Compared structures

2X7G · Structure of human serine-arginine-rich protein-specific kinase 2 (SRPK2) bound to… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C9JQJ0
Elsewhere: RCSB PDB 2X7G · PDBe 2X7G · UniProt C9JQJ0

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