MolNFT v1 · #53793 · protein
X-ray structure of the substrate-free mycobacterium tuberculosis cytochrome P450 CYP125, alternative crystal form
2X5L · Putative cytochrome P450 125: “X-ray structure of the substrate-free mycobacterium tuberculosis cytochrome P450 CYP125, alternative crystal…”. X-ray diffraction, 1 ligand (HEM), 2 pockets (best druggability 0.84). MolNFT v1 #53793…
- PDB
- 2X5L
- Type
- protein
- Length
- 414 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative cytochrome P450 125
- EC
- 1.14.-.-
- UniProt
- P63709
- Ligands
- HEM
- Pockets
- 2 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 49% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative cytochrome P450 125 (EC 1.14.-.-) | protein | 414 | 49% helix, 11% strand | P63709 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 901 | 0.84 | 0.85 | 96 | HEM |
| 2 | 90 | 0.41 | 0.77 | 17 | empty |
Compared structures
- 2X5L · X-ray structure of the substrate-free mycobacterium tuberculosis cytochrome P450 CYP125… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63709
- Elsewhere: RCSB PDB 2X5L · PDBe 2X5L · UniProt P63709
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.